Dr. Hsieh's laboratory investigates mechanisms of innate immunity that impact disease outcomes and seeks to identify targets and therapeutics to modulate immunity to ameliorate disease. A primary focus of Dr. Hsieh's lab is to understand macrophage and microglia responses during neuroinflammation and neurodegeneration using an experimental model of traumatic brain injury (TBI). Through collaborations, Dr. Hsieh also investigates frontotemporal dementia (FTD), cardiac injury, and stroke.

There are two major areas of research in Dr. Bikle's lab. The first is the study of vitamin D and calcium in regulating keratinocyte differentiation, skin cancer, wound healing. The second is the study of IGF1 regulation of skeletal development, fractures, response to mechanical load and osteoarthritis.

Dr. Mathalon's laboratory studies brain dysfunction in schizophrenia using various brain imaging techniques including EEG, event-related brain potentials, and functional magnetic resonance imaging. He is particularly interested in whether functional brain abnormalities, as assessed with these methods, can be used as markers in individuals at high risk for schizophrenia to improve our ability to predict who will go on to convert to psychosis.

I am a physician-investigator. I care for patients with advanced cancer who are hospitalized and patients with genitourinary malignancies, such as prostate cancer. My research interests involve improving patient-centered outcomes for patients with cancer. This includes patient decision-making support, outcomes research, survivorship, cognition, and biomarkers. I use both qualitative and quantitative methods, as well as implementation science methods.

Dr. Shoback's laboratory is working on how extracellular calcium-sensing receptors (CaSRs) sense changes in the extracellular calcium in the serum and in the bone microenvironment to alter cellular functions. These receptors play critical roles in parathyroid and kidney function that have been well-established through human, animal and cell-based studies. Her laboratory has shown a key role for the CaSR in bone-forming cells and we hope to demonstrate a role for this molecule in different stages of fracture repair.