Loop diuretic (LD) use may lead to a prescribing cascade whereby urinary symptoms are ascribed to genitourinary syndromes and treated with urinary symptom medications (USMs).  

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Drs. Michael Steinman and John Boscardin joined researchers to investigate if LDs lead to increased USM use among older adults and whether this potential prescribing cascade varies across key characteristics, in the study titled: “Loop diuretics and subsequent use of urinary symptom medications in older adults: evaluation of a possible prescribing cascade”.

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The study was published in The Journals of Gerontology: Series A.

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Nearly 20% of hospitalized older adults are discharged to a skilled nursing facility (SNF) for short-term rehabilitation. Many subsequently experience adverse outcomes, such as hospital readmissions, transitioning to long-term care rather than returning home, or death.

To guide shared decision making, Drs. John Boscardin, Alexander K. Smith, and Sei Lee helped develop a prognostic model for multiple outcomes for older adults admitted to SNFs.

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The three co-published a retrospective cohort study titled “A Multi-Outcome Prognostic Model for Community-Dwelling Older Adults Admitted to Skilled Nursing Facilities for Post-Acute Care”. The study was published in the Journal of the American Medical Directors Association.

NCIRE congratulates Dr. Shira Maguen for receiving the Robert S. Laufer Memorial Award for Outstanding Scientific Achievement from the International Society for Traumatic Stress Studies (ISTSS)!

 

Dr. Maguen is the Mental Health Director of the Post-9/11 Integrated Care Clinic and a Staff Psychologist on the PTSD Clinical Team at the San Francisco VA Health Care System. She also serves as Interim Vice Chair at SFVAHCS and Professor in the Department of Psychiatry and Behavioral Sciences at UCSF. Her research and clinical work center on PTSD, moral injury, and suicide, with a focus on female veterans. Dr. Maguen has authored over 200 peer-reviewed publications and continues to lead groundbreaking work in veteran mental health.

 

The award is given to an individual or group who has made an outstanding contribution to research in the field of traumatic stress. The ISTSS presented Dr. Maguen with the award at its 41st Annual Meeting, in Baltimore, Maryland, September 17-20, 2025.

 

Dr. Maguen was also nominated for the Women of UCSF Health Spotlight in August.

 

Nominated by Christina Mantel, MA, Dr. Maguen was recognized for her scholarly impact as a respected mentor, educator, and team builder. 

Somatic genetic mosaicism is a leading cause of disease across the human lifespan, yet there is still a limited understanding of how mosaicism affects both normal tissue development and disease pathogenesis.

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The study, published by Dr. Kelly Wentworth, titled “Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells” sought to understand the contributions of cellular mosaicism and the effects of variant-bearing cells on the surrounding microenvironment in skeletal development using Fibrous dysplasia, a prototypical disease of mosaic Gs-GPCR activation caused by somatic, post-zygotic variants in GNAS.

 

This study was funded in part by grant R01AR081336 via subaward agreement and published in American Journal of Human Genetics.