Research News

Dr. Duygu Tosun-Turgut and research team named semifinalists for the Alzheimer's Insights AI Prize!
November 18, 2025
Congratulations to Dr. Duygu Tosun-Turgut and her research team for being named semifinalist for the Alzheimer’s Disease Data Initiative (AD Data Initiative) $1 million Alzheimer's Insights AI Prize!
The AD Data Initiative seeks to tap into the potential to accelerate the pace of discovery and development of Alzheimer’s research.
Dr. Tosun-Turgut’s team will be presenting their power pitch at the Alzheimer's Insights Summit in San Diego on Dec 5th. The winner will be announced the week of March 16th, 2026.
NCIRE wishes you the best of luck in your research endeavor.
Full list of the semifinalist: https://www.linkedin.com/posts/alzheimersdata_alzheimers-insights-ai-prize-semifinalists-activity-7386447874047504384-LJqD?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAAOy3AB4KLiKX6_Mk-RTjvqgttTnOcVMNI
Learn more: https://www.alzheimersdata.org/alzinsights-prize-for-adrd-research

Discordance in creatinine based eGFR and cystatin C based eGFR and clinical outcomes: a meta-analysis
November 18, 2025
Do individuals with a cystatin C–based estimated glomerular filtration rate (eGFRcys) value at least 30% lower than their creatinine-based estimated glomerular filtration rate (eGFRcr) have higher rates of mortality, cardiovascular events, and kidney failure compared with individuals whose eGFRcys is not at least 30% lower than their eGFRcr?
Dr. Michelle Estrella and her Kidney Health Research Collaborative (KHRC) colleagues, Drs. Michael Shlpak and Teresa Chen, joined other researchers to answer that question through a study titled “Discordance in creatinine based eGFR and cystatin C based eGFR and clinical outcomes: a meta-analysis”, published in the Journal of the American Medical Association (JAMA).
Dr. Estrella is the Executive Director of the KHRC, Dr. Shlipak is the co-founder/Scientific Director and Dr. Chen’s is part of the Associated Faculty. Dr. Shlipak also serves as Chair of the NCIRE Board.
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To view the study, click "Learn More" below.
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Learn more about the KHRC: https://khrc.ucsf.edu/

Social Participation Among Older Adults Before and After Long-Term Care Facility Entry
November 13, 2025
Social participation is essential throughout life and is associated with decreased mortality and increased quality of life. It is unknown whether long-term care facility entry disrupts or facilitates it.
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Drs. Alexander K. Smith and Kenneth E. Covinsky, along with their research colleagues, set out to answer the question: How does social participation change before and after moving into a nursing home or assisted living facility?
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To read more about the cohort study, titled “Social Participation Among Older Adults Before and After Long-Term Care Facility Entry”, published in the Journal of the American Medical Association Internal Medicine, click "Learn More" below.

​Moral injury is independently associated with suicidal ideation and suicide attempt in high-stress, service-oriented occupations
October 29, 2025
Dr. Shira Maguen co-published a study that explores the link between moral injury and suicidal thoughts and behaviors among US military Veterans, healthcare workers, and first responders.
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Titled “Moral injury is independently associated with suicidal ideation and suicide attempt in high-stress, service-oriented occupations”, the study investigates the risk associated with moral injury that is not attributable to common mental health issues.

Loop diuretics and subsequent use of urinary symptom medications in older adults: evaluation of a possible prescribing cascade
October 20, 2025
Loop diuretic (LD) use may lead to a prescribing cascade whereby urinary symptoms are ascribed to genitourinary syndromes and treated with urinary symptom medications (USMs).
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Drs. Michael Steinman and John Boscardin joined researchers to investigate if LDs lead to increased USM use among older adults and whether this potential prescribing cascade varies across key characteristics, in the study titled: “Loop diuretics and subsequent use of urinary symptom medications in older adults: evaluation of a possible prescribing cascade”.
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The study was published in The Journals of Gerontology: Series A.
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A Multi-Outcome Prognostic Model for Community-Dwelling Older Adults Admitted to Skilled Nursing Facilities for Post-Acute Care
October 17, 2025
Nearly 20% of hospitalized older adults are discharged to a skilled nursing facility (SNF) for short-term rehabilitation. Many subsequently experience adverse outcomes, such as hospital readmissions, transitioning to long-term care rather than returning home, or death.
To guide shared decision making, Drs. John Boscardin, Alexander K. Smith, and Sei Lee helped develop a prognostic model for multiple outcomes for older adults admitted to SNFs.
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The three co-published a retrospective cohort study titled “A Multi-Outcome Prognostic Model for Community-Dwelling Older Adults Admitted to Skilled Nursing Facilities for Post-Acute Care”. The study was published in the Journal of the American Medical Directors Association.