A recently published study in the journal nature titled “Hierarchical organization of tau topography across the Alzheimer’s disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability” used data from the NCIRE-supported NIH Alzheimer's Disease Neuroimaging Initiative (ADNI).

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Led by Dr. Michael Weiner, the ADNI study actively supports the investigation and development of treatments that slow or stop the progression of Alzheimer’s disease (AD). Researchers at over 60 clinical sites in the USA and Canada collect data to study the progression of AD in the human brain across normal aging, mild cognitive impairment (MCI), and Alzheimer’s disease and dementia.

A recent AAMC News article featured Dr. Michael Steinman and the U.S. Deprescribing Research Network (USDeN), which he co-leads, in a discussion of the growing challenge of polypharmacy among older adults and the importance of deprescribing—safely reducing or discontinuing medications that may be unnecessary or harmful.

Congratulations to Dr. Kenneth Covinsky, who was honored as the 2026 SGIM Distinguished Professor of Geriatrics by the Society of General Internal Medicine at its May 2026 meeting in Washington D.C.  At the meeting, Covinsky gave a presentation titled “On Being a Generalist and a Geriatrician”. His talk ranged from hospital acquired disability to prognosis to disparities. At the conclusion of his talk, Covinsky received a lengthy standing ovation and a Chicago Cubs Jersey with his name and the year. 

Dementia is a major and growing global challenge in aging societies, affecting an estimated 57 million people worldwide, with the fastest growth occurring in low and middle-income countries (LMICs).

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Drs. Kenneth Covinsky and Sei Lee co-published a new manuscript entitled "Undiagnosed dementia and mortality among older adults in the United States and Brazil: A cross-national cohort study" in Alzheimer’s & Dementia: The Journal of the Alzheimer's Association that evaluates proportion of undiagnosed dementia, associated factors, and mortality in the two countries.

Outpatient palliative care (OPC) is increasingly being delivered virtually but symptom-related outcomes associated with virtual OPC are unknown.

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Drs. Rebecca Sudore and John Boscardin co-authored the study “Impact of Virtual vs. In-Person Palliative Care on Symptom Burden: A Multisite Cohort Study” that examines the association over time between symptom burden and visit modality among people with serious illnesses.

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The study was published in Journal of Pain and Symptom Management.

Dr. Kristine Yaffe, NCIRE Board Member and a Society for Equality in Neuroscience (SEQUINS) Hall of Fame honoree, discusses dementia prevention, modifiable risk factors, and ongoing disparities in brain health and cognitive aging in a Q&A published by NeurologyLive.

Emotional and financial mistreatment among older adults is often under-recognized among clinicians.

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Dr. Alexander K. Smith co-authored a study that explores whether sensory impairment is linked to an elevated risk of elder financial or emotional mistreatment could help inform targeted screening strategies.

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The study, titled “Sensory Impairment and Risk of Elder Mistreatment in Community-Dwelling Older Adults” was published in the Journal of the American Geriatrics Society.

Assessing cognition in individuals with or at risk of Alzheimer's disease (AD), is crucial for clinical and differential diagnosis, monitoring disease progression and evaluating the effects of pharmaceutical or lifestyle interventions.

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Dr. Michael Weiner, with the NCIRE-supported NIH Alzheimer's Disease Neuroimaging Initiative (ADNI), contributed to the ad hoc study to assess the acceptability, validity and sensitivity of the Cogstate Brief Battery (CBB) under supervised in-clinic settings, unsupervised remote contexts compared to supervised in-clinic administration, and examine the sensitivity of the remote CBB to early AD-related cognitive decline in individuals with preclinical and prodromal AD.

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The study was published in Alzheimer’s & Dementia: The Journal of the Alzheimer's Association.