S. Marlene Grenon, MD, CM
Vascular Surgeon and Associate Professor of Surgery, UCSF
Vascular Rehabilitation: Improving Lifestyle Factors for Patients With Cardiovascular Diseases.
My current research program focuses on lifestyle modifications and vascular rehabilitation for patients with vascular disease. It is well known that lifestyle issues including nutrition, physical activity, and emotional stress have a high impact on disease development and rehabilitation in patients with heart disease. The evidence for how nutrition, physical activity, and emotional stress affect patients with other vascular diseases such as peripheral artery disease (PAD) is less clear. In my research program, we are conducting different clinical studies on how these factors impact PAD, with the aim to improve the quality of life and outcomes of patients with vascular diseases.
OMEGA-PAD I Trial (completed): In this double-blind, randomized control trial, we investigated the hypothesis that short-term (1 month), high-dose n-3 PUFA supplementation improves endothelial function and inflammation in patients with stable claudication.
OMEGA-PAD II Trial (enrolling): In this double-blind, randomized control trial, we are investigating the hypothesis that high-dose n-3 polyunsaturated fatty acids (PUFA) oral supplementation improves systemic inflammation, vascular function, and symptomatic status of patients with PAD. We are also exploring novel mechanistic pathways by which n-3 PUFA affect PAD, evaluating the role of specialized lipid mediators involved in the resolution of inflammation.
OMEGA-PVI Trial (enrolling): In this double-blind, randomized control trial, we are addressing the hypothesis that high-dose n-3 polyunsaturated fatty acids (PUFA) oral supplementation will improve will improve systemic inflammation and patency of peripheral vascular intervention (PVI).
To see Dr. Grenon on PubMed, click here.