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NCIRE-The Veterans Health Research Institute is the leading private nonprofit institute devoted to Veterans health research in the United States. Our mission is to advance Veterans health through research.

We support the work of some of the nation's foremost physicians and scientists at the San Francisco Veterans Affairs Medical Center, the premier biomedical research facility in the VA system. All have faculty appointments at the University of California, San Francisco, which has its own proud traditions of research and patient care. We also partner with the U.S. Department of Defense to support health research on behalf of our men and women in the Armed Forces.

Those who have served in uniform have given their best for their country. In return, we believe that they deserve nothing less than the best health care research we can provide.

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Gerald B. Matson, PhD

Facilities Manager, Center for the Imaging of Neurodegenerative Diseases, SFVAHCS
Adjunct Professor of Pharmaceutical Chemistry, UCSF

Email: gerald.matson@ucsf.edu

Designing Improved Methods for Human Brain Spectroscopy

Dr. Matson's work has been directed toward developing improved methods to measure human brain metabolites - products of brain metabolism - by using magnetic resonance spectroscopy (MRS). The goal of this work is better, more accurate diagnosis of brain diseases. He developed improved methods to preserve brain metabolite signals that normally decay rapidly, making them difficult to quantify. This work should lead to more accurate signal measurement of brain metabolites including myo-inositol, which has been observed at higher levels in persons with Alzheimer's disease, and glutamate, a neurotransmitter whose level may be altered in a variety of brain diseases. In addition, Dr. Matson is interested in RF pulse design, and is using optimal control methods to explore new RF pulse designs for MR imaging and spectroscopy.

To see Dr. Matson on Pub Med, click here.