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About NCIRE - The Veterans Health Research Institute
NCIRE's Impact on Veterans Veteran's Health Research Researchers by Name
There's no question that the San Francisco VA Medical Center, with the support of NCIRE, plays a major role in advancing veterans health care through research. The excellence of our NCIRE and SFVAMC investigators, all of whom are UC San Francisco faculty members, is fundamental to our success in developing cutting edge knowledge that will advance medical treatments of veterans and others, both locally and worldwide.

Paul Volberding, MD
Chair, NCIRE Board of Directors
Chief of Medicine, SFVAMC

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John McLeod Griffiss, MD

Staff Physician, Medical Service, SFVAMC
Professor of Medicine and Laboratory Medicine, UCSF

Email: crapaud@loursage.org

Studies in Immunology

Dr. Griffiss studies the immunochemistry of Neisseria gonorrhoeae, the bacteria that cause the sexually transmitted disease gonorrhea. He also conducts research in the epidemiology and immunochemistry of Neisseria meningitidis, which cause meningitis, and gram-negative sepsis, of which there are hundreds of thousands of cases a year in the United States. Related research concerns bacterial outer membrane glycolipids -- compounds on the outer surfaces of bacteria that provide energy and serve as markers for cell recognition. Other research areas include immunologic function of the immunoglobulin A system; immunology of bacterial vaccines; tumor glycobiology; and Gulf War illness.

Stewart L, Griffiss JM, Jarvis GA, Way LW. 2007. Bacteria entombed in the center of cholesterol gallstones induce fewer infectious manifestations than bacteria in the matrix of pigment stones. J Gastrointest Surg 11(10):1298-308.

O'Connor ET, Zhou H, Bullock K, Swanson KV, Griffiss JM, Reinhold VN, Miller CJ, Stein DC. 2009. Structural characterization of an oligosaccharide made by Neisseria sicca. J Bacteriol (Epub ahead of print).