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Kristine Yaffe, MD

Low blood levels of beta-amyloid 42, a protein-like substance, were associated with the risk of significant cognitive decline within nine years in a group of elders, in a study led by Kristine Yaffe, MD , chief of geriatric psychiatry at the San Francisco VA Medical Center. Beta-amyloid 42 has long been known to collect in the brain of patients with Alzheimer's disease. The study also showed that, among the elders with low beta-amyloid 42, cognitive decline was less pronounced in those who had higher literacy, or more education, or who lacked the APOE e4 gene known to be associated with a greater risk of dementia. The researchers describe this set of conditions as "cognitive reserve."
The study appears in the January 19, 2011 issue of the Journal of the American Medical Association.
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Gary M. Abrams, MD
Conrad C. Alano, PhD
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Anthony J. Baker, PhD
Deborah E. Barnes, PhD
Steven L. Batki, MD
Caroline Behler, MD, MS
Stephen Bent, MD
Daniel D. Bikle, MD, PhD
W. John Boscardin, PhD
Lilly Y.W. Bourguignon, PhD
Jennifer E. Boyd, PhD
James K. Brown, MD
Marek Brzezinski, MD, PhD
Martha Buffum, DNSc, RN, PMHCNS-BC
William Byerley, MD
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Valerie Cardenas-Nicholson, PhD
Timothy P. Carmody, PhD
George H. Caughey, MD
Gary Cecchini, PhD
Wenhan Chang, PhD
Linda Chao, PhD
Anthony J. W. Chen, MA, MD
Steven W. Cheung, MD
Mary-Margaret Chren, MD
Beth Cohen, MD MAS
Matthew R. Cooperberg, MD, MPH
Kenneth Covinsky, MD, MPH
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Rajvir Dahiya, PhD
David I. Daikh, MD, PhD
Timothy C. Durazzo, PhD
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Peter M. Elias, MD
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Kenneth Feingold, MD
Judith M. Ford, PhD
James A. Frank, MD
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Grant E. Gauger, MD
Liang Ge, PhD
Ruby Ghadially, MBCHB, FRCP
Deborah Grady, MD, MPH
Mary O. Gray, MD
John McLeod Griffiss, MD
Carl Grunfeld, MD, PhD
Julius M. Guccione, Ph.D.
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Bernard Halloran, PhD
Walter M. Holleran, PharmD
Eric J. Huang, MD, PhD
Millie Hughes-Fulford, PhD
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Geon-Ho Jahng, PhD
Sharad Jain, MD
Gary Jarvis, PhD
Kirsten Johansen, MD
Meshell D. Johnson, MD
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Nick Kanas, MD
Joel S. Karliner, MD
Tiina Kauppinen, PhD
Karla Kerlikowske, MD
Edmund Keung, MD
Hubert T. Kim, MD, PhD
Sara J. Knight, PhD
Alfred C. Kuo, MD, PhD
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Harry Lampiris, MD
Seth Landefeld, MD
Yun-Fai Chris Lau, PhD
Sei J. Lee, MD, MAS
Daniel A. Lim, MD, PhD
Jialing Liu, PhD
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Shira Maguen, PhD
Michael J. Mann, MD
William J. Marks, Jr., MD
Stephen Massa, MD, PhD
Barry M. Massie, MD
Daniel H Mathalon, MD, PhD
Gerald B. Matson, PhD
Theodora Mauro, MD
Shannon McCaslin-Rodrigo, PhD
William S. McIntire, PhD
Kala M. Mehta, PhD
Dieter Johannes Meyerhoff, Dr. rer. nat
Alex Monto, MD
Susanne G. Mueller, MD
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Mary C. Nakamura, MD
Thomas C Neylan, MD
Robert A. Nissenson, PhD
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Dennis H. Oh, MD, PhD
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S. Scott Panter, PhD
Lynn Pulliam, MS, PhD
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Robert L. Raffai, PhD
Joseph Rapp, MD
Mark Ratcliffe, MD
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David Saloner, PhD
Norbert Schuff, PhD
Karen Seal, MD, MPH
William Seaman, MD
Amandeep Shergill, MD
Michael G. Shlipak, MD, MPH
Dolores Shoback, MD
Kendrick A. Shunk, MD, PhD
Joel A. Simon, MD, MPH
Paul C. Simpson, MD
Alexander K. Smith, MD, MS, MPH
Michael Steinman, MD
Rebecca Sudore, MD
Sang Won Suh, MD, PhD
Paul M. Sullam, MD
Raymond A. Swanson, MD
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John R. Teerlink, MD
Phyllis C. Tien, MD
Elaine Tseng, MD
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Yoshikazu Uchida, PhD
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Donald A. Vessey, PhD
Sophia Vinogradov, MD
Paul Volberding, MD
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Arthur Wallace, MD, PhD
Louise C. Walter, MD
Maria L. Wei, MD, PhD
Michael W. Weiner, MD
Mary Whooley, MD
Brie Williams, MD, MS
David Wofsy, MD
Joseph K. Wong, MD
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Zhongjian Xie, MD, PhD
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Kristine Yaffe, MD
Judy Yee, MD
Benjamin M. Yeh, MD
Midori A. Yenari, MD
Karl Young, PhD
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Wang Zhan, PhD
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